Clinical burden of community-associated infections caused by multidrug-resistant Pseudomonas aeruginosa: a propensity-matched longitudinal cohort study in Southern China
Our latest research article was just published in GMS Hygiene and Infection Control, October 23, 2024.
Clinical burden of community-associated infections caused by multidrug-resistant Pseudomonas aeruginosa: a propensity-matched longitudinal cohort study in Southern China
by
Mouqing Zhou, Baohua Xu, Zhusheng Guo, Yongfeng Zeng, Jiayao Lei, Evangelos I. Kritsotakis, and Jiancong Wang
Open Access to the full paper is available via:
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- PubMed (PMID: tbc)
- PMC (PMCID: tbc)
Abstract
Background: Limited research has been conducted on the burden of community-associated infections caused by multidrug-resistant Pseudomonas aeruginosa (CA-MDRPa). We quantitatively modeled the incidence rate and clinical factors associated with CA-MDRPa among hospitalized patients in Southern China.
Methods: Data were obtained from the local nosocomial surveillance system. Poisson regression was applied to estimate annual incidence rate ratios (IRRs) from 2018 to 2021. After propensity-score 1:2 matching, multivariable conditional logistic regression was used to identify factors for CA-MDRPa upon admission and adverse clinical outcomes during hospitalization.
Results: 278 patients were clinically and microbiologically diagnosed with CA-MDRPa and 647 with CA-non-MDRPa. CA-MDRPa rate exhibited a slight, non-significant, increase during the research period (IRR=1.03; 95% confidence interval [CI], 0.93–1.15). Neurological conditions, cardiovascular diseases, respiratory disorders, urinary tract infections, and use of cefoperazone/sulbactam prior to admission were identified as risk factors for CA-MDRPa upon admission. CA-MDRPa upon admission was associated with ESBL-producing P. aeruginosa acquisition during hospitalization (odds ratio [OR], 2.70; 95% CI, 1.53–4.77) and increased in-hospital mortality (OR, 2.24; 95% CI, 1.17–4.28).
Conclusions: The findings emphasize the importance of regular targeted screening for CA-MDRPa upon hospital admission and offer valuable insights for strengthening infection control and antimicrobial stewardship programs.
Keywords: community-associated infections, Pseudomonas aeruginosa, multidrug-resistant pathogens, incidence density, age- and sex-specific, China, Dongguan
Figure 2: Distributions of CA-MDRPa and CA-non-MDRPa cases stratified by age and sex
Table 1: Multivariable analysis of clinical factors associated with CA-MDRPa upon admission using conditional and mixed effects logistic regression models in the propensity-score-matched dataset (n=834 observations)